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In short, an “endotoxin” is a structural component of bacteria. The cell wall of Gram-negative bacteria contains an extra layer in its structure, called the outer membrane, in addition to the peptidoglycan layer. Endotoxin is a component of this outer membrane.

This structure, which is briefly defined as a structural component of bacteria, is formed when bacteria lose this normal structure for various reasons. In a sense, it is a degraded bacterial structure.

In summary, endotoxins are the last weapon of gram-negative bacteria before they die.

The Bacterial Endotoxin (LAL) Test is the detection of toxic structures in the cell wall of gram-negative bacteria on the product. It is an essential parameter in medical devices in contact with the body (in vitro), in the pharmaceutical industry and especially in dialysis water.

Bacterial endotoxin analyses are performed according to the following standards.

European Pharmacopeiae (E.P.) 2.6.14-Bacterial Endotoxins

United States Pharmacopeiae (USP)-85-Bacterial Endotoxins Test